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KMID : 0942820110100020055
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Journal of Korean Brain Tumor Society
2011 Volume.10 No. 2 p.55 ~ p.60
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Pilocytic Astrocytoma : Clinical Features and Outcomes of 20 Patients
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Hur Jung-Woo
Bae Jung-Sik
Yang Seung-Ho
Jeun Sin-Soo
Park Chun-Kun
Kim Moon-Chan
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Abstract
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Objective: Most pilocytic astrocytomas (PA) are benign tumors. However, there can be a bad outcome according to the patient’s age, the degree of tumor resection and the location in which the established outcomes have not yet been reported. We therefore analyzed and evaluated the outcome and features of PAs in a retrospective study.
Methods: We retrospectively analyzed 20 patients who were treated at our hospital between 1995 and 2009. Age, Karnofsky Performance Scale (KPS) score, tumor location, the degree of tumor resection, tumor recurrence or malignant transformation, the disease progression-free survival (PFS) rate and the overall survival (OS) rate were examined.
Results: The mean age of the patients was 18.0±13.6 years. The mean PFS and OS rates were 53.3±49.2 months and 62.7±52.1 months. Twelve patients were less than 16 years of age and 8 patients were 16 years of age or older with the mean PFS rates 72.4±52.7 months and 24.6±25.5 months, respectively. Nine patients (45%) had tumor recurrence or progression and the mean PFS rate was 41.3±37.2 months. Among the recurrence group, the patients younger than 16 (5 cases) had a longer mean PFS (65.8±34.3 months) than the patients who was 16 or older (4 cases ; 11.8±12.2 months). Other factors did not show statistically significant differences in the PFS and OS rates.
Conclusion: Generally, PA patients have a good prognosis. However, a bad prognosis can occur in adult patients, particularly with incomplete resection. Therefore, aggressive operations should be performed to prevent recurrence in older patients. Additionally, even though radical tumor resections are done, we should be aware of tumor recurrences, especially within the first 4 years after the operation.
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KEYWORD
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Pilocytic astrocytoma, Malignant transformation, Disease progression-free survival, Overall survival(247 words)
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